Mucolytic to facilitate expectoration by reducing sputum viscosity.

• Adult: by inhalation of powder, over initiation dose (see product literature), then 400 mg, twice daily. The dose should be administered 5–15 minutes after a bronchodilator and before physiotherapy. The second daily dose should be taken 2–3 hours before bedtime.

Reduction of sputum viscosity. 

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Mucolytic to facilitate expectoration.

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Mucolytic to facilitate expectoration.

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Mucolytic to facilitate expectoration.

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Mucolytic to facilitate expectoration.

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Mucolytic to facilitate expectoration.

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Mucolytic to facilitate expectoration.

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Mucolytic to facilitate expectoration.

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Mucolytic to facilitate expectoration.

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves

Mucolytic to facilitate expectoration.

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Mucolytic to facilitate expectoration.

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Mucolytic to facilitate expectoration.

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Mucolytic to facilitate expectoration.

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Mucolytic to facilitate expectoration.

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Mucolytic to facilitate expectoration.

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Mucolytic to facilitate expectoration.

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Mucolytic to facilitate expectoration.

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Mucolytic to facilitate expectoration.

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Mucolytic to facilitate expectoration.

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Mucolytic to facilitate expectoration.

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Mucolytic to facilitate expectoration.

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Mucolytic to facilitate expectoration by reducing sputum viscosity.

• Over 18 years: 300 mg, twice daily for up to 10 days.

Mucolytic to facilitate expectoration by reducing sputum viscosity in the case of cystic fibrosis.

Kaftrio 37.5 mg/25 mg/500 mg
Child 6–11 years (body-weight up to 30 kg): 2 tablets, to be taken in the morning and, Ivacaftor 75 mg to be taken in the evening (about 12 hours apart).

Kaftrio 75 mg/50 mg/100 mg
Child over 6 years with body weight greater than 30 kgs and adult: 2 tablets to be taken in the morning in combination with Ivacaftor 150 mg in the evening.

A cystic fibrosis transmembrane conductance regulator (CFTR) protein potentiator that increases chloride transport in the abnormal CFTR protein.

By mouth using granules
Child 4–5 months (body-weight 5 kg and above): 25 mg every 12 hours.
Child 6 months–17 years (body-weight 5–6 kg): 25 mg every 12 hours.
Child 6 months–17 years (body-weight 7–13 kg): 50 mg every 12 hours.
Child 6 months–17 years (body-weight 14–24 kg): 75 mg every 12 hours.

By mouth using tablets
Child 6–17 years (body-weight 25 kg and above): 150 mg every 12 hours.
Adult: 150 mg every 12 hours – specialist use only.

Mucolytic to facilitate expectoration by reducing sputum viscosity.

MucoClear 3%
Inhalation of nebulised solution, 4 ml, 2–4 times daily.
MucoClear 6%
Inhalation of nebulised solution, 4 ml, twice daily.

Mucolytic to facilitate expectoration.

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Mucolytic to facilitate expectoration by reducing sputum viscosity.

Nebusal 7%
Inhalation of nebulised solution, 4 ml, up to twice daily.

Lumacaftor increases the number of proteins that each the cell surface. Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) protein potentiator that increases chloride transport in the abnormal CFTR protein.

By mouth using granules
Child 2–5 years (body-weight up to 14 kg): 100/125 mg every 12 hours.
Child 2–5 years (body-weight 14 kg and above): 150/188 mg every 12 hours.

By mouth using tablets
Child 6–11 years: 200/250 mg every 12 hours.
Child 12–17 years: 400/250 mg every 12 hours.
Adult: 400/250 mg every 12 hours – specialist use only.

Mucolytic 

Osmohale is used for an indirect osmotic bronchial challenge test which can be used to identify bronchial hyperresponsiveness, a clinical feature of some respiratory conditions such as asthma.

Contraindications: Use with caution in renal impairment and to avoid in pregnancy. The Osmohale test should not be used in patients below 6 years of age due to their inability to provide reproducible spirometric measurements.

There is limited information on the use of Osmohale in patients 6-18 years of age therefore Osmohale is not recommended in this population.

Dose: See manufacturers’ instructions for more information. The test should be repeated until the patient has a positive response or 635 mg has been administered. 

Mucolytic to facilitate expectoration by reducing sputum viscosity.

• Over 5 years: inhalation of nebulised solution (by jet nebuliser), 2,500 units (2.5 mg) once daily (patients over 21 years may benefit from twice daily dosage).

Mucolytic to facilitate expectoration by reducing sputum viscosity.

4ml nebuliser solution up to twice daily undiluted. It can be used in conjunction with chest hygiene clearance which has been assessed in secondary care.

Mucolytic to facilitate expectoration by reducing sputum viscosity in the case of cystic fibrosis.

By mouth
Child 6–11 years (body-weight up to 30 kg): 50/75 mg, to be taken in the morning and, Ivacaftor 75 mg to be taken in the evening (about 12 hours apart).
Child 6–11 years (body-weight 30 kg and above): 100/150 mg, to be taken in the morning and, Ivacaftor 150 mg to be taken in the evening (about 12 hours apart).
Child 12–17 years: 100/150 mg, to be taken in the morning and, Ivacaftor 150 mg to be taken in the evening (about 12 hours apart).
Adult: 100/150 mg, to be taken in the morning in combination with Ivacaftor 150 mg in the evening.