Respiratory Handbook
For UK audiences

The professional's guide to product selection

DuoResp Spiromax - Budesonide with formoterol
Bronchodilators Compound preparations Teva

DuoResp Spiromax - Budesonide with formoterol

Long-acting selective beta2 agonist with corticosteroid.

DuoResp Spiromax 160 mcg/4.5 mcg
• Adult for asthma maintenance: one to two inhalations twice daily, and up to four inhalations twice daily.
• Adult for asthma maintenance and reliever therapy: two inhalations twice daily across one or two doses, and increased to two inhalations twice daily if needed. One inhalation taken as required to relieve symptoms and increased up to six if needed but with a maximum of eight inhalations per day. Up to 12 inhalations can be taken per day for a limited time under medical supervision.
• Adult for COPD: two inhalations twice daily.

DuoResp Spiromax 320 mcg/9 mcg
• Adult for asthma maintenance: one inhalation twice daily, but increased to two inhalations twice daily if required.
• Adult for COPD: one inhalation twice daily.

Indications

Maintenance and reliever therapy for asthma and used for the treatment of COPD.

Preparations Available

Inhalation powder

Sizes Available

Inhalation powder
DuoResp Spiromax 160 mcg/4.5 mcg/dose, 120 doses 
DuoResp Spiromax 320 mcg/9 mcg/dose, 60 doses 

Price

Bronchodilators

All Bronchodilators
Acopair - Tiotropium
Viatrus UK Healthcare Ltd

Acopair - Tiotropium

Antimuscarinic bronchodilator.

• Over 18 years for maintenance of COPD: by inhalation of powder, one capsule, once daily.

Aloflute and Sirdupla - Salmeterol and fluticasone propionate
Viatrus UK Healthcare Ltd

Aloflute and Sirdupla - Salmeterol and fluticasone propionate

Long-acting selective beta2 agonist with corticosteroid.

Prophylaxis of moderate-to-severe asthma for Aloflute® 25/125 by inhalation of aerosol
Adult: 2 inhalations twice daily.

Prophylaxis of moderate-to-severe asthma for Aloflute® 25/250 by inhalation of aerosol
Adult: 2 inhalations twice daily.

Duaklir - Aclidinium bromide with formoterol
Covis Pharma Europe B.V.

Duaklir - Aclidinium bromide with formoterol

Long-acting selective beta2 agonist with long-acting muscarinic antagonist.

Adult: one inhalation twice daily. 

Eklira Genuair - Aclidinium bromide
Covis Pharma Europe B.V.

Eklira Genuair - Aclidinium bromide

Antimuscarinic bronchodilator.

• Over 18 years: by inhalation of powder, 375 mcg (1 inhalation), twice daily.

Salbulin Novolizer - Salbutamol
Viatrus UK Healthcare Ltd

Salbulin Novolizer - Salbutamol

Short-acting selective beta2 agonist.

For acute bronchospasm, Salbulin Novolizer® by inhalation of powder
Adult: Initially 100–200 micrograms, up to 800 micrograms daily for persistent symptoms.

For prophylaxis of allergen- or exercise-induced bronchospasm, Salbulin Novolizer® by inhalation of powder
Adult: 200 micrograms.

Salbutamol - AAH Pharmaceuticals Ltd
AAH Pharmaceuticals

Salbutamol - AAH Pharmaceuticals Ltd

Short-acting selective beta2 agonist.

Oral
(Please note, inhalation route preferred over oral route in children.)
• Child 1 month–1 year: 100 mcg/kg (maximum 2 mg) 3–4 times daily
• Child 2–5 years: 1–2 mg, 3–4 times daily
• Child 6–11 years: 2 mg, 3–4 times daily
• Child 12–17 years: 2–4 mg, 3–4 times daily
• Over 18 years: 4 mg (elderly and sensitive patients initially 2 mg), 3–4 times daily, with a maximum single dose of 8 mg (but unlikely to provide much extra benefit or to be tolerated).

Moderate to severe or life-threatening acute asthma, treated by inhalation of nebulised solution. Give via a large volume spacer, and via a close-fitting face mask in children under 3 years.
• Child 1 month–4 years: 2.5 mg, repeat every 20–30 minutes or when required.
• Child 5–11 years: 2.5–5 mg, repeat every 20–30 minutes or when required.
• Over 12 years: 5 mg, repeat every 20–30 minutes or when required.

Compound preparations

All Compound preparations
Aloflute and Sirdupla - Salmeterol and fluticasone propionate
Viatrus UK Healthcare Ltd

Aloflute and Sirdupla - Salmeterol and fluticasone propionate

Long-acting selective beta2 agonist with corticosteroid.

Prophylaxis of moderate-to-severe asthma for Aloflute® 25/125 by inhalation of aerosol
Adult: 2 inhalations twice daily.

Prophylaxis of moderate-to-severe asthma for Aloflute® 25/250 by inhalation of aerosol
Adult: 2 inhalations twice daily.

Bevespi Aerosphere - Glycopyrronium with formoterol fumarate
AstraZeneca

Bevespi Aerosphere - Glycopyrronium with formoterol fumarate

Long-acting muscarinic antagonist, Long-acting beta 2 agonist.

Adult: two inhalations twice daily.

Duaklir - Aclidinium bromide with formoterol
Covis Pharma Europe B.V.

Duaklir - Aclidinium bromide with formoterol

Long-acting selective beta2 agonist with long-acting muscarinic antagonist.

Adult: one inhalation twice daily. 

Symbicort - Budesonide with formoterol (1)
AstraZeneca

Symbicort - Budesonide with formoterol (1)

Long-acting selective beta2 agonist with corticosteroid.

Symbicort 100/3 pressurised inhaler
Asthma, maintenance therapy
• Child 12–17 years: Initially 2–4 inhalations twice daily; reduced to 1 inhalation daily, dose reduced only if control is maintained.
• Adult: Initially 2–4 inhalations twice daily, increased if necessary up to 8 inhalations twice daily; reduced to 1 inhalation daily, dose reduced only if control is maintained.
Asthma, maintenance and reliever therapy
• Over 12 years: Maintenance 4 inhalations daily in 1–2 divided doses, increased if necessary up to 4 inhalations twice daily; 2 inhalations as required for relief of symptoms, increased if necessary up to 12 inhalations as required, usual max. 16 inhalations per day; up to 24 inhalations daily can be used for a limited time under medical supervision.

Symbicort 200/6 Pressurised inhaler
COPD
• Adult: 2 inhalations twice daily.

Symbicort Turbohaler - Budesonide with formetrol
AstraZeneca

Symbicort Turbohaler - Budesonide with formetrol

Long-acting selective beta2 agonist with corticosteroid.

Symbicort 100/6 Turbohaler
• 6–17 years for asthma maintenance: 1-2 inhalations twice daily, reduced to 1 inhalation daily if controlled.
• Adults for asthma maintenance: 1-2 inhalations daily, increased to up to 4 inhalations daily if needed, or reduced to 1 daily if controlled.
• Over 12 years for asthma maintenance and reliever therapy: 2 inhalations daily across one or two doses; 1 inhalation for relief of symptoms and increase to 6 if required. A maximum of 8 inhalations per day, but 12 can be given under medical supervision.

Symbicort 200/6 Turbohaler
• 12–17 years for asthma maintenance: 1-2 inhalations twice daily, reduced to 1 inhalation daily if controlled.
• Adults for asthma maintenance: 1-2 inhalations daily, increased to up to 4 inhalations daily if needed, or reduced to one daily if controlled.
• Over 12 years for asthma maintenance and reliever therapy: 2 inhalations daily across one or two doses but can be increased to 2 inhalations twice daily if needed; 1 inhalation for relief of symptoms and increase to 6 inhalations if required. A maximum of 8 inhalations per day, but 12 can be given for a limited time under medical supervision.
• Adult for COPD: 1 inhalation twice daily.

Symbicort 400/12 Turbohaler
• 12–17 years for asthma maintenance: 1 inhalation twice daily, but can be reduced to 1 inhalation daily.
• Adult for asthma maintenance: 1 inhalation twice daily, increased to 2 inhalations twice daily if required and decreased to 1 inhalation daily if controlled.
• Adult for COPD: 1 inhalation twice daily.

Trixeo Aerosphere - Formoterol fumarate with glycopyrronium and budesonide
AstraZeneca

Trixeo Aerosphere - Formoterol fumarate with glycopyrronium and budesonide

Long acting muscarinic antagonist, long-acting beta 2 agonist and inhaled corticosteroid.

Two inhalations twice daily