Respiratory Handbook
For UK audiences

The professional's guide to product selection

Pulmozyme - Dornase alfa
Mucolytics Dornase alfa Roche

Pulmozyme - Dornase alfa

Mucolytic to facilitate expectoration by reducing sputum viscosity.

• Over 5 years: inhalation of nebulised solution (by jet nebuliser), 2,500 units (2.5 mg) once daily (patients over 21 years may benefit from twice daily dosage).

Indications

To improve the pulmonary function of cystic fibrosis patients with a forced vital capacity (FVC) of >40% of predicted.

Sizes Available

Pulmozyme nebuliser solution, 2.5 mg/2.5 ml ampoules, 30 ampoules 

Price

Mucolytics

All Mucolytics
Carbocisteine - AAH Pharmaceuticals Ltd
AAH Pharmaceuticals

Carbocisteine - AAH Pharmaceuticals Ltd

Reduction of sputum viscosity. 

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Carbocisteine - Accord Healthcare Ltd
Accord Healthcare

Carbocisteine - Accord Healthcare Ltd

Mucolytic to facilitate expectoration.

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Carbocisteine - Esteve
Esteve

Carbocisteine - Esteve

Mucolytic to facilitate expectoration.

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Carbocisteine - Typharm
Typharm

Carbocisteine - Typharm

Mucolytic to facilitate expectoration.

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Carbocisteine - Viatrus
Viatrus UK Healthcare Ltd

Carbocisteine - Viatrus

Mucolytic to facilitate expectoration.

• Child 2–4 years: 62.5–125 mg, 4 times daily
• Child 5–11 years: 250 mg, 3 times daily
• Over 12 years: initially 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Osmohale - Mannitol - Chapper Healthcare
Chapper Healthcare

Osmohale - Mannitol - Chapper Healthcare

Mucolytic 

Osmohale is used for an indirect osmotic bronchial challenge test which can be used to identify bronchial hyperresponsiveness, a clinical feature of some respiratory conditions such as asthma.

Contraindications: Use with caution in renal impairment and to avoid in pregnancy. The Osmohale test should not be used in patients below 6 years of age due to their inability to provide reproducible spirometric measurements.

There is limited information on the use of Osmohale in patients 6-18 years of age therefore Osmohale is not recommended in this population.

Dose: See manufacturers’ instructions for more information. The test should be repeated until the patient has a positive response or 635 mg has been administered.